Chang Lab

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The main focus of the Chang Laboratory is to determine the mechanisms underlying chronic rhinosinusitis (CRS); a complex heterogeneous disorder affecting 15 million people in the United States with costs exceeding 11 billion dollars per year. Dr. Chang is a physician-scientist who provides medical and surgical care for those with upper airway (nasal, sinus, and skull base) disorders. Currently our therapies include medications and surgeries that treat the symptoms of disease. Our goal is to utilize modern molecular techniques to identify the primary cause and translate these findings to improve therapies for our patients.

Our research interests include:

  • CFTR-related sinus disease: identify the mechanism of disease for those with cystic fibrosis (two CFTR mutations) and CF carriers (single CFTR mutation).

  • Rhinovirus and unified airway disease: Rhinovirus is implicated in chronic rhinosinusitis, asthma, and COPD exacerbations. Our goal is to identify the genome-virome epithelial response in airway epithelia.

  • Craniofacial sinus modeling: use of 3-d volumetric CT imaging to quantify sinus morphology and mucosal disease.

  • Improving physician-patient communication: utilizing personalized video teachings and recordings to improve patient medical recall and satisfaction.



Congratulations to upcoming conference presenters!

American Academy of Allergy Asthma and Immunology, March 3-6, 2017. Atlanta, GA, USA

Oral Presentations:

  • Role of Rhinovirus in rhinosinusitis and asthma. Eugene H. Chang
  • Histamine enchances Rhinovirus C binding in differentiated sinus epithelial culture. Amanda L. Willis


  • Expression of surfactant protein A in human nasal epithelial cells after infection with Rhinovirus C in the presence of histamine. George Noutsios

American Rhinologic Society, September 16-17, 2016. San Diego, CA, USA

Oral Presentations:

  • The longitudinal impact of genetics and clinical interventions on the microbiome of patients with chronic rhinosinusitis. Amanda L. Willis, Joshua B. Calton, Daniel Laubitz, Eugene H. Chang
  • Association between the CDHR3 SNP (rs6967330) risk allele and chronic rhinosinusitis. AL Willis, JB Calton, HC McCrary, NA Cohen, Fernando D Martinez MD, EH Chang
  • Partial loss of CFTR function in CF carriers leads to craniofacial sinus hypoplasia and increased incidence of chronic rhinosinusitis. Joshua B. Calton, Amanda L. Willis, Pradeep C. Koripella, Erin G. Romero, Christopher H. Le, Alexander G. Chiu, Eugene H. Chang


  • Effects of rhinovirus infection on patient-derived air-liquid interface cultures. Sean L Kent, Amanda L Willis, Erin Romero, George Noustios, Eugene H. Chang
  • Challenges of reconstructing sino-cranial-orbital tumor defects. Sean Kent, Chris Le, Audrey Erman, Michael Lemole, Eugene Chang
  • Determining barriers to customized web-based rhinology education. Hilary C. McCrary, Sean L. Kent, Cynthia R. Thompson, Eugene H. Chang, Christopher H. Le