• Where laboratory research meets clinical application

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The main focus of the Chang Laboratory is to determine the mechanisms underlying chronic rhinosinusitis (CRS); a complex heterogeneous disorder affecting 15 million people in the United States with costs exceeding 11 billion dollars per year. Dr. Chang is a physician-scientist who provides medical and surgical care for those with upper airway (nasal, sinus, and skull base) disorders. Currently our therapies include medications and surgeries that treat the symptoms of disease. Our goal is to utilize modern molecular techniques to identify the primary cause and translate these findings to improve therapies for our patients.

Our research interests include:

  • CFTR-related sinus disease: identify the mechanism of disease for those with cystic fibrosis (two CFTR mutations) and CF carriers (single CFTR mutation).

  • Rhinovirus and unified airway disease: Rhinovirus is implicated in chronic rhinosinusitis, asthma, and COPD exacerbations. Our goal is to identify the genome-virome epithelial response in airway epithelia.

  • Craniofacial sinus modeling: use of 3-d volumetric CT imaging to quantify sinus morphology and mucosal disease.

  • Improving physician-patient communication: utilizing personalized video teachings and recordings to improve patient medical recall and satisfaction.



Undergraduate Eric Lee presented his summer project: Mastering qPCR Techniques.

Undergraduate Sophia Volpe presented her summer project: Plasmid Construction of a Proximity Labeling System for CDHR3

Congratulations to the conference presenters at the 2021 Otolaryngology Virtual Research Symposium!

Congratulations to undergraduate Eric Lee on his acceptance into the Undergraduate Biology Research Program (UBRP) for Summer 2021!

Congratulations to Dr. Eric Bailey on his graduation from the NeuroRhinology Fellowship Program!


Manuscript accepted to JACI and to be featured on AAAAI website

Dr. Chang's manuscript titled, "Early life risk factors for chronic sinusitis: a longitudinal birth cohort study" was accepted by the Journal of Allergy and Clinical Immunology (JACI) and is featured in the "Latest Research" section on the AAAAI website. You can read the AAAAI summary here and the publication abstract here.  

American Academy of Allergy Asthma and Immunology, March 2-5, 2018. Orlando, FL, USA

Oral Presentations:

  • Symptom severity from RV infections are increased in those with unified airway disease. Jaeden T. Calton

  • Early life risk factors for chronic sinusitis: a longitudinal birth cohort study. Amanda L. Willis and Eugene H. Chang

Congratulations to the upcoming conference presenters!