CDHR3 Study
This study provides a unique opportunity to investigate the role of rhinovirus infections and genetic risk factors in chronic rhinosinusitis (CRS) using in vitro cultures and in vivo human studies. We are identifying molecular mechanisms in the pathophysiology of CRS, with a specific focus on determining if RV-C infections in individuals with the rs6967330 CDHR3 risk allele predispose persons to CRS exacerbations. This research is relevant to public health, as the development of targeted strategies has the potential to reduce the incidence and severity of viral upper respiratory infections and CRS exacerbations.
NASAL Study
The Nasal Airway and Sinus Asthma Lung (NASAL) study is a database of patients with upper respiratory diseases in the greater Tucson area. The purpose of the NASAL study is to improve our ability to understand, accurately diagnose, and eventually treat diseases such as allergic rhinitis, CRS, and asthma. The risk factors for developing these disorders are not well understood. Scientists who study allergic rhinitis, CRS, and asthma use a variety of samples collected from the respiratory tract to identify chemicals, microbes, and cells involved in these conditions. We hope to learn more about how nasal and sinus disorders can influence the lower airway, and vice versa.